Lipoxan New Formula

From the constant research of the Yamamoto Research R&D team comes Lipoxan New Formula, a dietary supplement developed to increase thermogenesis, stimulate metabolism and support weight-loss programmes. Lipoxan New Formula is indeed a functional ally to be used during low-calorie diets aimed at body weight reduction or as a support for physical activity. Thanks to its natural formula, rich in raw materials with proven effects, Lipoxan New Formula can support and stimulate metabolism and participate in maintaining body weight balance. Its unique composition boasts the synergic action of synephrine obtained from bitter orange extract, green coffee (45% chlorogenic acids and 5% caffeine), green tea, rich in polyphenols and EGCG, caffeine anhydrous, capsaicin obtained from chilli pepper and the extract of Aframomum melegueta, also known as grains of paradise.

The extracts of green tea, green coffee and chilli pepper have been specially selected for their contribution to balancing body weight (green tea), for their tonic and metabolic support action (green coffee) and for stimulating metabolism (chilli pepper). These 3 extracts (green tea, green coffee, chilli pepper) have an antioxidant action, while caffeine helps improve concentration and increase alertness.

We will now take a closer look at how the plant extracts contained in Lipoxan New Formula work.

Synephrine, obtained from the unripe fruit of Citrus amarantum (bitter orange), is a sympathomimetic amine used for weight-loss purposes and as a stimulant, excitant and thermogenic. This extract promotes the mobilisation of fat and reduction of adipose tissue, as well as reducing appetite and stimulating basal metabolism (causes an increase in calorie expenditure).

Green coffee, obtained from coffee beans that have not yet undergone roasting, has a high proportion of chlorogenic acid (45%), a plant active ingredient with interesting pharmacological activities, and to a lesser extent than normal coffee, caffeine (5%). It is believed that chlorogenic acid can lead to several health benefits, including blood glucose modulation, an antioxidant effect and, above all, regulation of metabolism through an inhibition of fat accumulation during adipogenesis.

Green tea, rich in catechins, polyphenols and EGCG, has a powerful antioxidant action and the ability to stimulate lipolysis by acting on localised fat in adipose tissue to promote its oxidation for energy. It also has an action on thermogenesis, increasing and stimulating metabolism.

Anhydrous caffeine is a potent stimulant that helps improve concentration, stamina and physical performance. It acts by increasing energy, raises the body temperature and consequently accelerates the metabolism.

Chilli peppers contain capsaicin, an alkaloid with analgesic and soothing effects. Even low dosages of this natural active ingredient can cause the burning sensation typical of chilli peppers. This stress causes the body to rapidly release adrenalin, causing us to feel a burst of energy.

Lipoxan's formula is then completed by the addition of Aframomum melegueta extract (titrated in 6-paradol), commonly known as grains of paradise. This plant, the “Guinea Pepper”, is known in phytotherapy for its stimulating and diuretic properties. The empirical use of the grains of this plant is mainly aimed at the digestive and intestinal sphere, but recent research has revealed other beneficial properties of these grains, particularly in the area of weight loss. Very interesting clinical studies have, in fact, confirmed that the intake of grains of paradise can gradually counteract the accumulation of fat by attaching to already existing body fat.

Thanks to these characteristics, Lipoxan New Formula is suitable for those who exercise regularly and/or follow a low-calorie diet. Taking this product can help accelerate the weight-loss process and improve metabolic activity, promoting the reduction of adipose tissue.

It is important to emphasise that the intake of Lipoxan New Formula must always be combined with an active lifestyle and a balanced diet, and that the product is suitable for vegetarian and vegan diets.

Scientific references

Harpaz E, Tamir S, Weinstein A, Weinstein Y. The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol. 2017 Jan 1;28(1):1-10. doi: 10.1515/jbcpp-2016-0090. PMID: 27824614.

Clark KS, Coleman C, Shelton R, Heemstra LA, Novak CM. Caffeine enhances activity thermogenesis and energy expenditure in rats. Clin Exp Pharmacol Physiol. 2019 May;46(5):475-482. doi: 10.1111/1440-1681.13065. Epub 2019 Feb 14. PMID: 30620415; PMCID: PMC6467726.

Bérubé-Parent S, Pelletier C, Doré J, Tremblay A. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br J Nutr. 2005 Sep;94(3):432-6. doi: 10.1079/bjn20051502. PMID: 16176615.

Okla M, Kim J, Koehler K, Chung S. Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis. Adv Nutr. 2017 May 15;8(3):473-483. doi: 10.3945/an.116.014332. PMID: 28507012; PMCID: PMC5421122.

*Tanaka E, Mitani T, Nakashima M, Yonemoto E, Fujii H, Ashida H. Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPAR*γ activation-dependent manner. J Nutr Biochem. 2022 Feb;100:108898. doi: 10.1016/j.jnutbio.2021.108898. Epub 2021 Nov 5. PMID: 34748921.

Saito M, Matsushita M, Yoneshiro T, Okamatsu-Ogura Y. Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men. Front Endocrinol (Lausanne). 2020 Apr 21;11:222. doi: 10.3389/fendo.2020.00222. PMID: 32373072; PMCID: PMC7186310.

Stohs SJ. Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-Synephrine. Phytother Res. 2017 Oct;31(10):1463-1474. doi: 10.1002/ptr.5879. Epub 2017 Jul 28. PMID: 28752649; PMCID: PMC5655712.