Ashwagandha KSM-66®

Ashwagandha KSM-66® is a Yamamoto Research dietary supplement that provides 600 mg of KSM-66®-certified dry Ashwagandha extract per dose, titrated to 5% of withanolides.

Ashwagandha (Withania somnifera), also known as Indian ginseng, is one of the most potent healing plants used since antiquity in Ayurvedic medicine for its tonic and adaptogenic effects, which can effectively combat both physical and mental fatigue.

For millennia, the root of this plant has been used as a tonic and adaptogenic plant remedy, capable of increasing the body's non-specific resistance in response to external stimuli such as stress, anxiety or fatigue, and simultaneously promoting better relaxation. Ashwagandha is also attributed anti-inflammatory, cardioprotective, neuroprotective and immune-stimulating properties.

But what does ‘adaptogenic effect’ mean?

Ashwaganda KSM-66® has the peculiarity of increasing the body's ability to adapt and optimally modulate the organic response to various stress situations, consequently regulating metabolic functions. It therefore allows the body to cope with stressful events, and contributes to mental well-being.

It appears to have an interesting effect on neuroreceptors, allowing GABA (Gamma-Aminobutyric Acid, one of the most potent inhibitory neurotransmitters in the central nervous system), to bind effectively to its receptors, consequently inhibiting the signals present in the response to stress.

What are the active substances of Ashwagandha KSM-66®?

Patented KSM-66® guarantees the finest quality Ashwagandha: it contains the highest concentration of withanolides possible for a food supplement, titrated to 5%. These molecules are steroid lactones, and together with the alkaloids and other phytochemical constituents, make up the 'pool' of active substances in ashwagandha.

KSM-66® ashwagandha root extract is also the focus of a great many scientific studies guaranteeing that it is of the highest quality and safe to use.

The extraction process used involves pre-treating the Ashwagandha roots with milk, a step that makes it possible to retain both the hydrophilic and the lipophilic components in the root extract, thereby preserving the full spectrum of active ingredients.

Ashwagandha KSM-66® is suitable for vegetarian diets, and each production batch is gluten tested to ensure it is safe for consumption by the coeliac population.

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Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev. 2000 Aug;5(4):334-46. PMID: 10956379.

Bhattacharya S.K., Bhattacharya A., Sairam K., Ghosal S. “Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.” Phytomedicine 2000 Dec;7(6):463-9.

Sengupta P, Agarwal A, Pogrebetskaya M, Roychoudhury S, Durairajanayagam D, Henkel R. Role of Withania somnifera (Ashwagandha) in the management of male infertility. Reprod Biomed Online. 2018 Mar;36(3):311-326. doi: 10.1016/j.rbmo.2017.11.007. Epub 2017 Dec 7. PMID: 29277366.

Kuboyama T, Tohda C, Komatsu K. Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases. Biol Pharm Bull. 2014;37(6):892-7. doi: 10.1248/bpb.b14-00022. PMID: 24882401.

Kuboyama T., Tohda C., Komatsu K. “Neuritic regeneration and synaptic reconstruction induced by withanolide A.” British Journal of Pharmacology 005 Apr;144(7):961-71.

Choudhary M.I., Yousuf S., Nawaz S.A., Ahmed S., Atta-ur-Rahman. “Cholinesterase inhibiting withanolides from Withania somnifera.” Chemical and Pharmaceutical Bulletin (Tokyo) 2004 Nov;52(11):1358-61.