Yamamoto® Research’s Setria® GLR Orosoluble Sticks is a dietary supplement in orosoluble stick form that provides 250 mg per daily dose of Setria® Reduced L-Glutathione. Glutathione is a potent antioxidant molecule that plays a key role in protecting the body against oxidative stress and the action of free radicals and is able to protect the hepatocytes against toxic molecules that can cause liver damage. The formulation in a handy orosoluble sticks ensures rapid dissolution and sublingual absorption, enabling the body to quickly and optimally absorb Glutathione from the sublingual venous circulation tributary to the superior vena cava, thus bypassing intestinal gamma-glutamyltransferase activity and avoiding the metabolic avidity of the enterocytes. It therefore escapes the *hepatic filter** and avoids the first-pass metabolism that usually takes place in the liver and deactivates a significant part of the glutathione molecule, thus making it less functional and effective.
One of our first lines of defence is Glutathione, a ubiquitous molecule, i.e. one that is present throughout our body, but that is particularly concentrated in the liver, where it protects liver cells from toxic molecules: in this case, Glutathione “binds” to and neutralises toxic metabolites. Reduced glutathione is in fact able to surrender its hydrogen (H+), which acts as an acceptor of electrons (e-) from reactive oxygen molecules, i.e. free radicals. At this point, having eliminated the danger caused by free radicals, glutathione can regain its antioxidant activity and return to its reduced form. Glutathione’s ability to continually regenerate itself is the reason why it is considered the most powerful antioxidant in the human body. The molecule's biological functions support its clinical utility in several situations, foremost among them its ability to protect the liver against the action of toxic substances.
In the past, the oral intake of glutathione was the limiting factor for its use in food supplements, as the human gut contains significant amounts of the enzyme gamma-glutamyltranspeptidase, which is responsible for the degradation of glutathione after oral ingestion. Consequently, the molecule was only truly effective when injected. Thanks to the special absorption route of Setria® GLR Orosoluble Sticks, a next-generation reduced glutathione supplement in a handy orosoluble stick form, it is possible to bypass the enzymatic steps responsible for the molecule's loss of effectiveness and ensure the body optimal bioavailability of glutathione.
Why is the effect of Glutathione so important?
Twenty-four hours a day, seven days a week, free radicals are busy attacking our bodies at cell level. Scientists have discovered that this constant onslaught has detrimental effects on health and well-being in general, including the health and ageing of our tissues. Fighting the damage caused by free radicals seems to enable us to age better and live healthier lives, which is why it is important to ensure our bodies optimal levels of glutathione, a molecule capable of effectively counteracting oxidative stress.
How can Setria® GLR Orosoluble Sticks help the body to fight free radicals?
Eating, exercising and even breathing are actions that can result in the formation of free radicals. Once formed, these molecules attack the body at cell level, stealing electrons from other molecules and triggering a chain reaction. GLR Sticks provides the body with reduced Glutathione, which binds to and neutralises free radicals.
Why is glutathione known as the 'Master antioxidant' or the 'King of antioxidants'?
Glutathione not only neutralises free radicals, it is also capable of reactivating other antioxidant molecules, like vitamins C and E. Normally, once antioxidants (e.g. vitamin C and vitamin E) have done their job by inactivating free radicals, they become unstable radicals themselves. Glutathione helps to recycle these molecules, restoring their function and extending their ability to attack free radicals, which is why Glutathione is considered the 'master' or 'King' molecule of all the body’s antioxidants.
How does Setria® GLR Orosoluble Sticks help eliminate toxins?
Glutathione supports the function of the liver, kidneys, gastrointestinal tract and intestines, the body's major detoxification pathways.
It acts on two different fronts:
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It helps eliminate toxins, ingested chemicals and potential carcinogens that the body has already absorbed;
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It intercepts and neutralises toxins in the gastrointestinal tract before they are absorbed.
Why can Setria® GLR Orosoluble Stick also be useful for athletes?
Scientific research seems to suggest that Setria® glutathione can support Nitric Oxide (NO) production when combined with L-Citrulline and when used in endurance performance.
**Setria® also appears to help maintain high levels of NO, which may reduce fatigue and accelerate recovery.
Sublingual Setria® GLR can therefore aid strength training by maintaining increased nitric oxide production after a training session.
**Patent Pending
Scientific references
Averill-Bates DA. The antioxidant glutathione. Vitam Horm. 2023;121:109-141. doi: 10.1016/bs.vh.2022.09.002. Epub 2023 Jan 13. PMID: 36707132.
Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63. doi: 10.1007/s00394-014-0706-z. Epub 2014 May 5. PMID: 24791752.
Gérard-Monnier D, Chaudiere J. Métabolisme et fonction antioxydante du glutathion [Metabolism and antioxidant function of glutathione]. Pathol Biol (Paris). 1996 Jan;44(1):77-85. French. PMID: 8734304.
Jones DP. Redefining oxidative stress. Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1865-79. doi: 10.1089/ars.2006.8.1865. PMID: 16987039.
Meister A. Glutathione metabolism and its selective modification. J Biol Chem. 1988 Nov 25;263(33):17205-8. PMID: 3053703.
