Epavid

30 Caplets

Support your liver’s health and your body's purifying processes naturally with Epavid

  • Supports liver function and purification
  • Based on Desmodium, Milk Thistle and Artichoke
-35%
Special Price £7.57 Regular Price £11.64 -35%
The product expires on 30/09/2024
Immediate availability Express delivery 1-3 days

The liver is a highly complex organ whose physiological function affects the health of the entire organism. It performs, coordinates and controls a variety of functions, always with a decisive influence on individual well-being. Among its many biological functions, the metabolic, detoxifying and bile-producing functions should certainly be highlighted. The liver is a true "multitasking" laboratory for our health; it intervenes in the metabolism of proteins, coagulation factors, the management of sugars (carbohydrates - it can store them in the form of glycogen and then return them to the bloodstream according to the body's energy requirements), the management of fats (lipids), the activity of various vitamins which, in order to perform their function, must first be metabolised by the liver. Not to be forgotten is its intervention in hormonal supervision: the production and secretion of many hormones is modulated by this special organ. From food to the introduction of drugs to any kind of exposure to substances, the liver plays an essential role through its detoxifying action. A series of complex chemical reactions take place in the liver that can modify substances or bind them to other molecules that act as transporters, making them easier to eliminate from the body. As mentioned above, the liver's fundamental task is also the production of bile, which has the main function of allowing the intestinal absorption of dietary fats and fat-soluble vitamins (A-D-E-K), as well as being the main vehicle for the elimination of numerous toxic substances, drugs and even excess cholesterol.
Given the continuous exposure of this organ to agents of various kinds, which we introduce or come into contact with directly or indirectly, and given the complexity of its functions, it is of great importance to be able to provide it with natural support in order to maintain the efficiency of its physiology.

What is Epavid
Epavid was developed to support regular liver function: a food supplement containing extracts of desmodium, milk thistle and artichoke, recognised for their natural support of liver physiological functions and in particular for their ability to maintain a healthy and efficient liver. Each individual component is chosen to support and enhance the functionality of our supplement.

Desmodium, known as Desmodium adscendens, is a plant native to many tropical areas of South America, Africa and Asia, but can also be found in Peru, Brazil, Bolivia, Cameroon, Ghana, Guinea, Mali and several other countries, where it grows in meadows and forests and is used in traditional medicine as a medicinal plant. Desmodium is rich in active ingredients and contains a high concentration of alkaloids, saponins, fatty acids (linoleic, oleic, palmitic), amino acids and minerals (mainly phosphorus, magnesium, sulphur, potassium). The action of this plant, which is widespread in Africa (from Senegal to Congo via the Ivory Coast), was made known by two French researchers, Dr Pierre Tubéry and his wife, Dr Anne-Marie Tubéry. This research couple discovered the beneficial effects of Desmodium as a natural remedy for hepatic well-being, earning it the name 'herb that cures yellow eye disease'. Following the French couple's research, Desmodium was approved in France and many other Western countries as a medicinal herb effective in restoring normal liver function, with no contraindications.

Milk thistle is a plant from the Asteraceae family, which is widespread throughout the Mediterranean area and whose botanical name is Silybum marianum. Its seeds, and in particular the flowering tops, yield valuable bioactive substances, first and foremost silymarin, as well as some bioflavonoids and substances such as polyunsaturated oils, taxifolin, quercetin and lapigenin. The silymarin in milk thistle has antioxidant and hepatoprotective properties, making it ideal for treating hepatocellular disease of various origins. This substance accelerates the process of liver regeneration, stimulates protein synthesis and protects against various potentially harmful substances such as alcohol. Silymarin's protective effect is achieved through various mechanisms of action: it can modify the cell membrane of hepatocytes, preventing toxic substances and toxins from penetrating them, and it increases hepatic levels of glutathione (an endogenous antioxidant), promoting regeneration of liver tissue.   The artichoke, whose scientific name is Cynara scolymus, is a vegetable with a wealth of interesting properties, cultivated everywhere as a vegetable. It is not only very pleasant to eat: its extracts have important effects, which are used to support liver function and digestion, thanks to its purifying properties. The artichoke plant and leaves contain bioactive substances such as sesquiterpenes, hydroxycinnamic acid and flavonoids. The eupeptic and stomachic action of the artichoke is due to both the sesquiterpenes and caffeine compounds, molecules that stimulate the appetite and increase acid secretion in the stomach, while also aiding the digestive processes. This plant also has cholesterol-lowering properties, which appear to be attributable to the inhibition of endogenous cholesterol synthesis in the liver.

Benefits of our supplement
Why choose Epavid:

  • Promotes liver function;
  • Supports depurative capacity;
  • Acts as a natural support for liver physiology;
  • Supports the cell regeneration processes of hepatocytes.

When and how to take it
It is recommended to take 2 tablets a day with water, before or after meals according to individual needs.   SCIENTIFIC REFERENCES
Rastogi S, Pandey MM, Rawat AK. An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC. J Ethnopharmacol. 2011 Jun 22;136(2):283-96. doi: 10.1016/j.jep.2011.04.031. Epub 2011 Apr 20. PMID: 21530632.

Magielse J, Arcoraci T, Breynaert A, van Dooren I, Kanyanga C, Fransen E, Van Hoof V, Vlietinck A, Apers S, Pieters L, Hermans N. Antihepatotoxic activity of a quantified Desmodium adscendens decoction and D-pinitol against chemically-induced liver damage in rats. J Ethnopharmacol. 2013 Mar 7;146(1):250-6. doi: 10.1016/j.jep.2012.12.039. Epub 2013 Jan 3. PMID: 23291573.

François C, Fares M, Baiocchi C, Maixent JM. Safety of Desmodium adscendens extract on hepatocytes and renal cells. Protective effect against oxidative stress. J Intercult Ethnopharmacol. 2015 Jan-Mar;4(1):1-5. doi: 10.5455/jice.20141013041312. Epub 2014 Nov 28. PMID: 26401376; PMCID: PMC4566765.

https://www.researchgate.net/publication/286523596\_Desmodium\_adscendens\_De\_l%27usage\_traditionnel\_camerounais\_contre\_les\_hepatites\_a\_l%27accompagnement\_des\_chimiotherapies

http://www.ethnopharmacologia.org/boutique/article-desmodium-adscendens-de-lusage-traditionnel-camerounais-contre-les-hepatites-aux-applications-contemporaines-en-europe-n53-aout-2015%EF%BF%BC/

Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010 Oct;24(10):1423-32. doi: 10.1002/ptr.3207. PMID: 20564545.

Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother Res. 2018 Nov;32(11):2202-2213. doi: 10.1002/ptr.6171. Epub 2018 Aug 6. PMID: 30080294.

Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol. 1998 Feb;93(2):139-43. doi: 10.1111/j.1572-0241.1998.00139.x. PMID: 9468229.

Federico A, Dallio M, Loguercio C. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules. 2017 Jan 24;22(2):191. doi: 10.3390/molecules22020191. PMID: 28125040; PMCID: PMC6155865.

Ben Salem M, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM. Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits. Plant Foods Hum Nutr. 2015 Dec;70(4):441-53. doi: 10.1007/s11130-015-0503-8. PMID: 26310198.

Panahi Y, Kianpour P, Mohtashami R, Atkin SL, Butler AE, Jafari R, Badeli R, Sahebkar A. Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Phytother Res. 2018 Jul;32(7):1382-1387. doi: 10.1002/ptr.6073. Epub 2018 Mar 9. PMID: 29520889.

Santos HO, Bueno AA, Mota JF. The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacol Res. 2018 Nov;137:170-178. doi: 10.1016/j.phrs.2018.10.007. Epub 2018 Oct 9. PMID: 30308247.

Horoszkiewicz M, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E. Karczoch zwyczajny- niewykorzystane mozliwości leku roślinnego w terapii miazdzycy i chorób watroby [Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases]. Przegl Lek. 2012;69(10):1129-31. Polish. PMID: 23421107.

Read more
Read less
Nutritional information
30 tablets
 
Nutrition information
Daily dose: 2 tablet
Servings per container: 15
   
  Per daily dose (2 tablet)
   
Desmodio 200 mg
Milk thistle 200 mg   
Artichoke 300 mg
of which chlorogenic acid 16,5 mg
   
Ingredients

bulking agents: cellulose, dicalcium phosphate; dry extract of artichoke ( Cynara scolymus L., leaf) 5% in chlorogenic acid, [dry extract of milk thistle ( Silybum marianum L. fruit), thickener: soy lecithin], dry extract of desmodium ( Desmodium adscendens (Sw.) DC., Leaf), anti-caking agents: magnesium salts of fatty acids, silicon dioxide.

Warnings
Do not exceed the recommended daily dose. Supplements are not intended as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of children under three years of age.
Read more
Read less
Directions and intake
Take 2 tablets a day with water.
Read more
Read less
Epavid - Sticky
Epavid
Special Price £7.57 Regular Price £11.64 -35%