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BlackGUARDIAN

60 tablets

A guardian for your liver, with antioxidant, purifying and gastrointestinal function-promoting effects.

  • Promotes liver function and purification
  • Favours gastrointestinal function
  • Formula based on a blend of eight active ingredients
  • With added milk thistle, turmeric and NAC
-35%
Special Price £17.55 Regular Price £27.00 -35%
The product expires on 31/10/2026
Immediate availability Express delivery 1-3 days
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BlackGUARDIAN is the dietary supplement from Yamamoto Nutrition developed to support liver purifying activity and gastrointestinal system functions and to exert a strong antioxidant action. The formula consists of 8 carefully selected ingredients that work in perfect synergy: extract of Milk thistle, NAC, Turmeric, Black Pepper, Inositol, Betaine, Folic Acid and Vitamin B12.

The liver plays a key role in our body. It oversees many biochemical functions, participates in metabolic reactions, acts as a filter to transform nutrients and is able to deactivate and remove the harmful toxins that we introduce in various ways (through the environment and diet). Given its crucial role, it is always advisable to act preventively to support the body's physiological detoxification processes and liver function, before chronic exposure to harmful substances can result in situations of metabolic imbalance.

Various natural extracts can help promote liver health: BlackGUARDIAN contains 8 of them, all of the highest quality and purity.

Milk thistle extract is highly valued for its antioxidant action and promotes digestive and hepatic function. It is rich in bioactive substances, first and foremost silymarin, as well as some flavonoids and polyunsaturated oils, taxifolin, quercetin and apigenin. Silymarin in particular can accelerate the liver regeneration process, stimulate protein synthesis and exert a protective action against various potentially harmful substances, such as alcohol. Its action has several mechanisms of action: it can modify the cell membrane of hepatocytes, preventing toxic substances and toxins from penetrating it, and it is able to increase liver levels of glutathione (the main endogenous antioxidant), thereby promoting the regeneration of liver tissue.

N-Acetylcysteine (NAC)** consists of the amino acid cysteine combined with the acetyl group. It is a very potent antioxidant, capable of increasing endogenous levels of glutathione and is commonly used to promote liver function, respiration and lung function, and to prevent free radical-induced damage.

Turmeric extract, which has been used for centuries in Chinese and Ayurvedic medicine, acts by increasing biliary secretion and consequently facilitates digestion, as well as being an important support for liver function. Its countless benefits are associated with the presence of particular substances called curcuminoids.

Inositol**, often incorrectly referred to as vitamin B7, is considered an effective detoxifier due to its action on the mitochondria (the energy powerhouses of the cells): it acts as a kind of transporter of information for various enzymatic and metabolic reactions, such as hormone activation processes and lecithin synthesis. It is also helps to reduce LDL-cholesterol levels in the blood.

Extract of Black Pepper promotes regular gastrointestinal motility and helps to eliminate tiresome gas, as well as improving digestive processes.

Betaine**, a natural substance extracted from sugar beet, is a well-known methylating agent. This is why it is successfully used to treat homocystinuria and hyperhomocysteinaemia, as well as having demonstrated hepatoprotective and lipotrophic effects and neuroprotective activity against alcohol-induced damage.

The formula also contains Folic Acid and Vitamin B12, which help to reduce tiredness and fatigue.

Scientific references
Cicero AFG, Colletti A, Bellentani S. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence. Nutrients. 2018 Aug 23;10(9):1153. doi: 10.3390/nu10091153. PMID: 30142943; PMCID: PMC6163782.

Aghemo A, Alekseeva OP, Angelico F, Bakulin IG, Bakulina NV, Bordin D, Bueverov AO, Drapkina OM, Gillessen A, Kagarmanova EM, Korochanskaya NV, Kucheryavii UA, Lazebnik LB, Livzan MA, Maev IV, Martynov AI, Osipenko MF, Sas EI, Starodubova A, Uspensky YP, Vinnitskaya EV, Yakovenko EP, Yakovlev AA. Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review. Ann Med. 2022 Dec;54(1):1548-1560. doi: 10.1080/07853890.2022.2069854. PMID: 35635048; PMCID: PMC9186366.

Saller R, Meier R, Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs. 2001;61(14):2035-63. doi: 10.2165/00003495-200161140-00003. PMID: 11735632.

Atilgan FA, Atescelik M, Yilmaz M, Turk A, Gurger M, Goktekin MC, Kuloglu T. Effects of N-acetyl cysteine on TRPM2 expression in kidney and liver tissues following malathion intoxication. Biotech Histochem. 2022 Jul;97(5):340-346. doi: 10.1080/10520295.2021.1986639. Epub 2021 Oct 15. PMID: 34652265.

Zhang X, Xu L, Ma W, Shi B, Liu Q, Song Y, Fang C, Liu P, Qiao S, Cai J, Zhang Z. N-acetyl-L-cysteine alleviated the oxidative stress-induced inflammation and necroptosis caused by excessive NiCl2 in primary spleen lymphocytes. Front Immunol. 2023 Apr 6;14:1146645. doi: 10.3389/fimmu.2023.1146645. PMID: 37090713; PMCID: PMC10117970.

Tasneem S, Liu B, Li B, Choudhary MI, Wang W. Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents. Pharmacol Res. 2019 Jan;139:126-140. doi: 10.1016/j.phrs.2018.11.001. Epub 2018 Nov 3. PMID: 30395947.

Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. PMID: 23143785; PMCID: PMC3535097.

Formoso G, Baldassarre MPA, Ginestra F, Carlucci MA, Bucci I, Consoli A. Inositol and antioxidant supplementation: Safety and efficacy in pregnancy. Diabetes Metab Res Rev. 2019 Jul;35(5):e3154. doi: 10.1002/dmrr.3154. Epub 2019 Apr 10. PMID: 30889626; PMCID: PMC6617769.

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Nutritional information

60 tablets

   

Media Analysis

   

Per dose 1 tablet

   
  Per dose (1 tablet)
 

N-acetylcysteine

300mg  

Milk thistle extract

250mg  

Turmeric extract

200mg  

Inositol

50mg  

Black pepper extract

1mg  

Betaine

100mg  

Folic acid

200mcg (100% *)  

Vitamin B12

33mcg (1320% *)  

* AR = Reference assumptions

 
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Ingredients

bulking agent: microcrystalline cellulose, N-acetylcysteine, Milk thistle (Silybum marianum (L.) Gaertn.) Fruits es tit. 80% silymarin, Curcuma (Curcuma longa L.) rhizome es tit. 95% total curcuminoids, betaine citrate, inositol, anti-caking agents: magnesium salts of fatty acids, silicon dioxide; Black pepper (Piper nigrum L.) fruits es tit. 95% piperine, pteroyl monoglutamic acid (folic acid), cyanocobalamin (Vitamin B12).

Warnings
Not recommended for children or pregnant women and in case of hepatic or biliary function disorders or gallstone disease. If you are taking any medications, you should consult your doctor. Consult your doctor also for long term intake. Do not exceed the recommended daily dose. Food supplements are not intended as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of reach of children under three years of age. In the event of impaired liver function, biliary function or gallstones, use of the product is not recommended. If you are taking medication, you should seek medical advice.
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Directions and intake
Take 1 tablet once a day with a glass of water.
Our Advice

Although there is no preferred time for taking BlackGUARDIAN, we recommend taking the daily tablet with a meal. This can improve the bioavailability of the active compounds present in Milk Thistle and may prevent gastro-intestinal or digestive disorders.

Frequently asked questions

Does taking BlackGUARDIAN interfere with the action of medication?

You should always consult your doctor before taking supplements, especially if you are already taking medication. The extract of milk thistle contained in BlackGUARDIAN may affect the metabolism of certain drugs that are metabolised by the liver, thereby resulting in increased side effects.

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Why choose it?

Why choose our supplement:

  • Supports liver function and health;
  • Supports gastro-intestinal system function;
  • Potent purifying and antioxidant action; counteracts the harmful action of free radicals;
  • 8 active ingredients to maximise well-being;
  • Milk Thistle, NAC, Turmeric, Black Pepper, functional natural active ingredients for a healthy body;
  • Ingredients of the highest quality and safety;
  • Produced entirely in Italy.
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BlackGUARDIAN - Sticky
BlackGUARDIAN
Special Price £17.55 Regular Price £27.00 -35%