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BlackGUARDIAN EVO

60 capsules

The evolution of supplementation for liver purification and function, with maximum bioavailability guaranteed by the liposomal form.

  • Promotes liver function and purification
  • Formula containing a blend of eight active substances
  • Silymarin in phytosomal® form for increased absorption and bioavailability
  • Certified Curcugreen™ turmeric for enhanced bioavailability
  • With added desmodium, which purifies and supports normal liver function
-75%
Special Price £9.01 Regular Price £36.03 -75%
The product expires on 31/03/2024
Immediate availability Express delivery 1-3 days
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BlackGUARDIAN EVO is the Yamamoto Nutrition dietary supplement developed to facilitate liver purification and gastrointestinal function and to exert a strong antioxidant action. The formula is composed of advanced and carefully selected ingredients that work in perfect synergy: extract of Milk Thistle with Liposomal Silymarin, Choline bitartrate, Betaine hydrochloride, Inositol, Curcuma CurcuGreen™ and extract of Desmodium.

The liver plays a key role in our body. It oversees many biochemical functions, is involved in metabolic reactions, acts as a filter to transform nutrients and is able to deactivate and remove the harmful toxins that we introduce in various ways (from the environment and diet). Given its crucial role, it is always advisable to act preventively to support the body's physiological detoxification processes and liver function, before chronic exposure to harmful substances can result in situations of metabolic imbalance.

Various natural extracts can help promote liver health: BlackGUARDIAN EVO contains state of the art phytoextracts to enhance the bioavailability and functionality of the active substances.

More specifically, it contains:

Milk thistle, which is highly valued for its antioxidant action and promotes digestive and hepatic function. It is rich in bioactive substances, first and foremost silymarin, as well as some flavonoids and polyunsaturated oils, taxifolin, quercetin and apigenin. Silymarin in particular can accelerate the liver regeneration process, stimulate protein synthesis and exert a protective action against various potentially harmful substances, such as alcohol. Its action has several mechanisms of action: it can modify the cell membrane of hepatocytes, preventing toxic substances and toxins from penetrating it, and it is able to increase liver levels of glutathione (the main endogenous antioxidant), thereby promoting the regeneration of liver tissue.

  • Choline Bitartrate
  • Curcuma CurcuGreen extract
  • Inositol
  • Extract of Desmodium

Choline Bitartrate: also known as vitamin B7 is an important nutrient with several functions. Without choline, fats can easily build up in the liver. Besides being part of the composition of cell membranes, this phospholipid also plays an important role in bile. Phosphatidylcholine, of which it is a precursor, is involved in fat emulsification, a process that facilitates the intestinal digestion of lipids. This mechanism allows phosphatidylcholine to reduce fat deposits and restrict cholesterol build up.

Betaine Hydrochloride, an effective lipotropic agent.

Inositol is one of the main components of membrane phospholipids and is essential for synthesising the myelin sheath surrounding nerves and therefore for proper nerve, muscle and brain function, but also acts as an important lipotropic agent.

Curcuma dry extract (Curcugreen®): turmeric belongs to the ginger family with which it shares its 'culinary' properties as well as its antioxidant action. Turmeric promotes liver function. Curcugreen® (i.e. Curcuma BCM95®) is used with the aim of presenting the best version of bioavailable curcumin in the safest way in terms of proven clinical efficacy.

Desmodium dry extract: gives a real new added value to this blend of components that deserves some attention and introduction. It is a perennial climbing plant native to many tropical areas of South America, Africa and Asia. It is widely used in Peru, Brazil, Bolivia, but also in African countries such as Cameroon, Ghana, Guinea and Mali to name but a few, where it grows in meadows and in forests reaching heights of 50 cm, with rich red flowers and green fruits that look like French beans. It is a plant that is very rich in active substances. It contains interesting levels of alkaloids, saponins, fatty acids (linoleic, oleic, palmitic), amino acids and minerals (mainly phosphorus, magnesium, sulphur, potassium). Desmodium was recently approved in France and many other western countries as a natural option that has a depurative action and promotes normal liver function.

The Extract of Turmeric, which has been used for centuries in Chinese and Ayurvedic medicine, acts by increasing biliary secretion and consequently facilitates digestion, as well as being an important support for liver function. Its countless benefits are associated with the presence of special substances called curcuminoids.

Inositol**, often incorrectly referred to as vitamin B7, is considered an effective detoxifier due to its action on the mitochondria (the energy powerhouses of the cells): it acts as a kind of transporter of information for various enzymatic and metabolic reactions, such as hormone activation processes and lecithin synthesis. It is also helps to reduce LDL-cholesterol levels in the blood.

Betaine**, a natural substance extracted from sugar beet, is a well-known methylating agent. This is why it is successfully used to treat homocystinuria and hyperhomocysteinaemia, as well as having demonstrated hepatoprotective and lipotrophic effects and neuroprotective activity against alcohol-induced damage.

Did you know that the silymarin in BlackGUARDIAN EVO is in phytosomal® form?

Being a pioneering brand, Yamamoto® always tries to give added value to its products, especially in terms of absorption and bioavailability.

What is a Phytosome®?

A Phytosome® is a structure whose active ingredient is anchored to the polar head of the phospholipid.

What are the advantages of using Silymarin in Liposomal® form?

Phytosomes® are an innovative transport system for active ingredients with poor bioavailability, to improve their absorption and bioavailability. Phytosomes® considerably increase biological activity when compared with the same dose of the active ingredient not treated with phytosome®.

Scientific references Cicero AFG, Colletti A, Bellentani S. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence. Nutrients. 2018 Aug 23;10(9):1153. doi: 10.3390/nu10091153. PMID: 30142943; PMCID: PMC6163782.

Aghemo A, Alekseeva OP, Angelico F, Bakulin IG, Bakulina NV, Bordin D, Bueverov AO, Drapkina OM, Gillessen A, Kagarmanova EM, Korochanskaya NV, Kucheryavii UA, Lazebnik LB, Livzan MA, Maev IV, Martynov AI, Osipenko MF, Sas EI, Starodubova A, Uspensky YP, Vinnitskaya EV, Yakovenko EP, Yakovlev AA. Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review. Ann Med. 2022 Dec;54(1):1548-1560. doi: 10.1080/07853890.2022.2069854. PMID: 35635048; PMCID: PMC9186366.

Saller R, Meier R, Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs. 2001;61(14):2035-63. doi: 10.2165/00003495-200161140-00003. PMID: 11735632.

Atilgan FA, Atescelik M, Yilmaz M, Turk A, Gurger M, Goktekin MC, Kuloglu T. Effects of N-acetyl cysteine on TRPM2 expression in kidney and liver tissues following malathion intoxication. Biotech Histochem. 2022 Jul;97(5):340-346. doi: 10.1080/10520295.2021.1986639. Epub 2021 Oct 15. PMID: 34652265.

Zhang X, Xu L, Ma W, Shi B, Liu Q, Song Y, Fang C, Liu P, Qiao S, Cai J, Zhang Z. N-acetyl-L-cysteine alleviated the oxidative stress-induced inflammation and necroptosis caused by excessive NiCl2 in primary spleen lymphocytes. Front Immunol. 2023 Apr 6;14:1146645. doi: 10.3389/fimmu.2023.1146645. PMID: 37090713; PMCID: PMC10117970.

Tasneem S, Liu B, Li B, Choudhary MI, Wang W. Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents. Pharmacol Res. 2019 Jan;139:126-140. doi: 10.1016/j.phrs.2018.11.001. Epub 2018 Nov 3. PMID: 30395947.

Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. PMID: 23143785; PMCID: PMC3535097.

Formoso G, Baldassarre MPA, Ginestra F, Carlucci MA, Bucci I, Consoli A. Inositol and antioxidant supplementation: Safety and efficacy in pregnancy. Diabetes Metab Res Rev. 2019 Jul;35(5):e3154. doi: 10.1002/dmrr.3154. Epub 2019 Apr 10. PMID: 30889626; PMCID: PMC6617769.

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Nutritional information

60 capsules

 

Nutrition facts

 

Daily dose: 1 capsule

 
Servings per container: 60  
  Per daily dose (1 capsule)
   

Milk thistle complex
of which milk thistle dry extract
of which silibinin

200 mg
66 mg
35 mg

Choline bitartrate

80 mg

Inositol

100 mg

Betaine

75,5 mg

Curcumin from turmeric (Curcugreen™)

237,5 mg

Desmodium dry extract
of which flavonoids

250 mg
1,25 mg
   
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Ingredients

turmeric dry extract Curcugreen™ (Curcuma longa L., rhizome) 45% total curcuminoids, desmodium dry extract (Desmodium adscendens (Sw.) DC., leaf) 0,5% flavonoids, silimarina [milk thistle dry extract (Silybum marianum (L.) Gaertn., fruit); 17,5% silymarin; soy lecithin], capsule (gelatin), inositol, betaine hydrochloride, choline bitartrate, bulking agent: cellulose; anti-caking agents: silicon dioxide, magnesium salts of fatty acids.

Warnings
Not recommended for children or pregnant women and in case of hepatic or biliary function disorders or gallstone disease. If you are taking any medications, you should consult your doctor. Consult your doctor also for long term intake. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of young children. Not recommended in case of liver disease, gallstones, obstruction of the bile duct, cholangitis, and any other biliary diseases. If you are taking any medications, please consult your physician before use.
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Directions and intake
Take 1 capsule a day with water.
Our Advice

Although there is no preferred time for taking BlackGUARDIAN, we recommend taking the daily tablet with a meal. This can improve the bioavailability of the active compounds present in Milk Thistle and may prevent gastro-intestinal or digestive disorders.

Frequently asked questions

Does taking BlackGUARDIAN interfere with the action of medication?

You should always consult your doctor before taking supplements, especially if you are already taking medication. The extract of milk thistle contained in BlackGUARDIAN may affect the metabolism of certain drugs that are metabolised by the liver, thereby resulting in increased side effects.

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Why choose it?

Why choose our supplement:

  • Supports liver function and health;
  • Supports gastro-intestinal system function;
  • Potent purifying and antioxidant action; counteracts the harmful action of free radicals;
  • 8 active ingredients to maximise well-being;
  • Milk Thistle, NAC, Turmeric, Black Pepper, functional natural active ingredients for a healthy body;
  • Ingredients of the highest quality and safety;
  • Produced entirely in Italy.
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BlackGUARDIAN EVO - Sticky
BlackGUARDIAN EVO
Special Price £9.01 Regular Price £36.03 -75%