Acetyl L-CARNITINE is Yamamoto Nutrition's dietary supplement containing L-Carnitine, an amino acid naturally synthesised by the human body that plays an important role in cell energy metabolism. More specifically, this supplement is formulated with a special form of L-Carnitine, which affords a greater bioavailability and capacity to cross the blood-brain barrier, which promotes brain function. This form of carnitine is uniquely characterised by the presence of an acetyl group, which facilitates the absorption of the molecule in the intestine, allowing it to cross the blood-brain barrier, the protective barrier separating the bloodstream from the brain.
Acetyl L-CARNITINE provides a high dose of Acetyl L-Carnitine, with a concentration of 1000 mg per capsule. This high concentration makes the food supplement an ideal solution for those who want to promote their physical and mental fitness, by improving their energy and resistance during physical activity and promoting better brain function.
L-Carnitine is a compound that is produced in the body from the essential amino acids lysine and methionine. Its main function is to transport long-chain fatty acids into the cells, where they can be metabolised to produce energy. It therefore plays an important role in energy metabolism, by promoting energy efficiency and production at cell level.
These characteristics mean that Acetyl L-Carnitine is able to promote optimal sports performance, by carrying fatty acids into the cells, where they are metabolised to produce energy. This process is particularly important during exercise, when the body needs a greater amount of energy to support muscle activity. In addition to promoting physical fitness, Acetyl L-Carnitine can also be useful for improving mental function and aiding memory and concentration, as this molecule is also present in the brain, where it plays an important role in energy production and protecting nerve cells from oxidative stress. The acetylated form of Carnitine, that chosen for Yamamoto Nutrition’s Acetyl L-CARNITINE, can cross the blood-brain barrier and promote better brain function. Carnitine can also play an important role in the prevention of certain illnesses, and its intake has been associated with a reduction in the risk of developing certain cardiovascular diseases, such as hypertension, heart attack and stroke, due to its ability to improve vascular health and reduce blood cholesterol levels, and it also plays a protective role against the development of certain neurodegenerative diseases, such as Alzheimer's and Parkinson's, due to its ability to protect nerve cells from oxidative stress.
**What is the difference between L-Carnitine and Acetyl L-Carnitine?
L-Carnitine and Acetyl L-Carnitine are two different forms of the same molecule, Carnitine, an amino acid naturally synthesised by the human body and plays an important role in cellular energy metabolism. The main difference lies in their chemical structure and their biological functions. L-Carnitine is a non-acetylated form of Carnitine, which plays an important role in transporting long-chain fatty acids to the cells, where they can be metabolised to produce energy. Acetyl L-Carnitine, on the other hand, is an acetylated form of Carnitine that differs due to the presence of an acetyl group. This acetyl group increases the solubility and bioavailability of Carnitine, promoting its better absorption in the intestine and its ability to cross the blood-brain barrier. Acetyl L-Carnitine therefore has a more specific action on brain function than L-Carnitine, and can be a useful aid for memory and concentration, improving cognitive function and counteracting brain ageing.
Scientific references
Traina G. The neurobiology of acetyl-L-carnitine. Front Biosci (Landmark Ed). 2016 Jun 1;21(7):1314-29. doi: 10.2741/4459. PMID: 27100509.
Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom Med. 2018 Feb/Mar;80(2):154-159. doi: 10.1097/PSY.0000000000000537. PMID: 29076953.
Ferreira GC, McKenna MC. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675. doi: 10.1007/s11064-017-2288-7. Epub 2017 May 16. PMID: 28508995; PMCID: PMC5621476.
Pekala J, Patkowska-Sokoła B, Bodkowski R, Jamroz D, Nowakowski P, Lochyński S, Librowski T. L-carnitine--metabolic functions and meaning in humans life. Curr Drug Metab. 2011 Sep;12(7):667-78. doi: 10.2174/138920011796504536. PMID: 21561431.
Cerretelli P, Marconi C. L-carnitine supplementation in humans. The effects on physical performance. Int J Sports Med. 1990 Feb;11(1):1-14. doi: 10.1055/s-2007-1024754. PMID: 2180829.
